I am trying to import openpyxl in order to start learning it, however whenever I try to import it it spits out this Traceback (most recent call last): File "D:\Py\test.py", line 3, in <module> import openpyxl File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\site-packages\openpyxl\__init__.py", line 6, in <module> from openpyxl.workbook import Workbook File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\site-packages\openpyxl\workbook\__init__.py", line 4, in <module> from .workbook import Workbook File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\site-packages\openpyxl\workbook\workbook.py", line 17, in <module> from openpyxl.writer.excel import save_workbook File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\site-packages\openpyxl\writer\excel.py", line 31, in <module> from openpyxl.packaging.manifest import Manifest File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\site-packages\openpyxl\packaging\manifest.py", line 42, in <module> mimetypes = MimeTypes() File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\mimetypes.py", line 74, in __init__ init() File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\mimetypes.py", line 368, in init db.read_windows_registry() File "C:\Users\[my_username]\AppData\Local\Programs\Python\Python310\lib\mimetypes.py", line 253, in read_windows_registry _mimetypes_read_windows_registry(add_type) PermissionError: [WinError 5] Access is denied In case it helps here is all the code I used import openpyxl I have tried to: Upgrade pip Take ownership of AppData\Local\Programs\Python Install pydirectory Run file as administrator Run file from administrator CMD Uninstalling and Reinstalling openpyxl With no impact Half-Solution. I found that downgrading from python 3.10.8 to 3.7 removed the error. Everything 3.8 onward crashes. Still have absolutely no clue as to why they crash. Continue reading...