import pandas as pd df = pd.read_csv('911.csv') df['desc'].str.replace('[^a-zA-Z0-9]','').head() 0 REINDEER CT & DEAD END; NEW HANOVER; Station ... 1 BRIAR PATH & WHITEMARSH LN; HATFIELD TOWNSHIP... 2 HAWS AVE; NORRISTOWN; 2015-12-10 @ 14:39:21-St... 3 AIRY ST & SWEDE ST; NORRISTOWN; Station 308A;... 4 CHERRYWOOD CT & DEAD END; LOWER POTTSGROVE; S... Name: desc, dtype: object I'm trying to remove all non-alphanumerical characters in the desc column. I tried the same code with other columns but it doesn't seem to be working. Continue reading...