My system Python version is 3.8.5, however I use pyenv to manage an additional version, 3.6.0, to mirror the server version my project is deployed to. I previously used virtualenv + virtualenvwrapper to manage my virtual environments, but I've heard great things on pipenv and thought I would give it a go. It's all great until I try using Python 3.6.0. Flow goes something like this: $ mkdir test_project && cd test_project $ pyenv shell 3.6.0 $ pipenv install django Creating a virtualenv for this project… Pipfile: /home/user/projects/test_project/Pipfile Using /home/user/.pyenv/shims/python (3.6.0) to create virtualenv… ⠸ Creating virtual environment...created virtual environment CPython3.8.5.final.0-64 in 130ms creator CPython3Posix(dest=/home/user/.local/share/virtualenvs/test_project-eAvoynKo-/home/user, clear=False, global=False) seeder FromAppData(download=False, pip=bundle, setuptools=bundle, wheel=bundle, via=copy, app_data_dir=/home/user/.local/share/virtualenv) added seed packages: pip==20.2.3, setuptools==50.3.0, wheel==0.35.1 activators BashActivator,CShellActivator,FishActivator,PowerShellActivator,PythonActivator,XonshActivator ✔ Successfully created virtual environment! Traceback (most recent call last): File "/home/user/.pyenv/versions/3.6.0/bin/pipenv", line 11, in <module> sys.exit(cli()) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 829, in __call__ return self.main(*args, **kwargs) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 782, in main rv = self.invoke(ctx) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 1259, in invoke return _process_result(sub_ctx.command.invoke(sub_ctx)) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 1066, in invoke return ctx.invoke(self.callback, **ctx.params) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 610, in invoke return callback(*args, **kwargs) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/decorators.py", line 73, in new_func return ctx.invoke(f, obj, *args, **kwargs) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/core.py", line 610, in invoke return callback(*args, **kwargs) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/vendor/click/decorators.py", line 21, in new_func return f(get_current_context(), *args, **kwargs) File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/cli/command.py", line 252, in install site_packages=state.site_packages File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/core.py", line 1928, in do_install site_packages=site_packages, File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/core.py", line 580, in ensure_project pypi_mirror=pypi_mirror, File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/core.py", line 512, in ensure_virtualenv python=python, site_packages=site_packages, pypi_mirror=pypi_mirror File "/home/user/.pyenv/versions/3.6.0/lib/python3.6/site-packages/pipenv/core.py", line 986, in do_create_virtualenv with open(project_file_name, "w") as f: FileNotFoundError: [Errno 2] No such file or directory: '/home/user/.local/share/virtualenvs/test_project-eAvoynKo-/home/user/.pyenv/shims/python/.project' I came across this previous question Pipenv not recognizing Pyenv version? and set the environment variable PIPENV_PYTHON="$PYENV_ROOT/shims/python in my .bashrc file. to no avail. Using the system Python version 3.8.5 works flawlessly: $ pyenv install django Creating a virtualenv for this project… Pipfile: /home/user/projects/test_project/Pipfile Using /home/user/.pyenv/shims/python (3.8.5) to create virtualenv… ⠹ Creating virtual environment...created virtual environment CPython3.8.5.final.0-64 in 114ms creator CPython3Posix(dest=/home/user/.local/share/virtualenvs/test_project-eAvoynKo-/home/user/.pyenv/shims/python, clear=False, global=False) seeder FromAppData(download=False, pip=bundle, setuptools=bundle, wheel=bundle, via=copy, app_data_dir=/home/user/.local/share/virtualenv) added seed packages: pip==20.2.2, setuptools==50.3.0, wheel==0.35.1 activators BashActivator,CShellActivator,FishActivator,PowerShellActivator,PythonActivator,XonshActivator ✔ Successfully created virtual environment! Virtualenv location: /home/user/.local/share/virtualenvs/test_project-eAvoynKo-/home/user/.pyenv/shims/python Creating a Pipfile for this project… Installing django… Adding django to Pipfile's [packages]… ✔ Installation Succeeded Pipfile.lock not found, creating… Locking [dev-packages] dependencies… Locking [packages] dependencies… Building requirements... Resolving dependencies... ✔ Success! Updated Pipfile.lock (a6086c)! Installing dependencies from Pipfile.lock (a6086c)… ▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉▉ 0/0 — 00:00:00 To activate this project's virtualenv, run pipenv shell. Alternatively, run a command inside the virtualenv with pipenv run. Update While I still can't get it to recognize the python version activated with pyenv shell x.x.x, by removing the PIPENV_PYTHON environment variable, and creating a new virtualenv with pipenv install --python 3.6 pipenv does recognize the pyenv version installed. Continue reading...