With a text file, I can write this: with open(path, 'r') as file: for line in file: # handle the line This is equivalent to this: with open(path, 'r') as file: for line in iter(file.readline, ''): # handle the line This idiom is documented in PEP 234 but I have failed to locate a similar idiom for binary files. With a binary file, I can write this: with open(path, 'rb') as file: while True: chunk = file.read(1024 * 64) if not chunk: break # handle the chunk I have tried the same idiom that with a text file: def make_read(file, size): def read(): return file.read(size) return read with open(path, 'rb') as file: for chunk in iter(make_read(file, 1024 * 64), b''): # handle the chunk Is it the idiomatic way to iterate over a binary file in Python? Continue reading...