I have a pandas dataframe which looks like this: 1_2 1_3 1_4 2_3 2_4 3_4 1 5 2 8 2 2 4 3 4 5 8 5 8 8 8 9 3 3 4 3 4 4 8 3 8 0 7 4 2 2 where the columns are the 4C2 combinations of 1,2,3,4. And I would like to generate 4 new columns f_1, f_2, f_3, f_4 where the values of the columns are defined to be df['f_1'] = df['1_2']+df['1_3']+df['1_4'] df['f_2'] = df['1_2']+df['2_3']+df['2_4'] df['f_3'] = df['1_3']+df['2_3']+df['3_4'] df['f_4'] = df['1_4']+df['2_4']+df['3_4'] In other words, the column f_i are defined to be the sum of columns i_j and k_i. So I can brute force my way in this case. However, my original dataframe is a lot bigger and there are 20C2 = 190 columns instead and hence a brute force method wouldn't work. So the desired outcome looks like 1_2 1_3 1_4 2_3 2_4 3_4 f_1 f_2 f_3 f_4 1 5 2 8 2 2 8 11 15 6 4 3 4 5 8 5 11 17 13 17 8 8 8 9 3 3 24 20 20 14 4 3 4 4 8 3 11 16 10 15 8 0 7 4 2 2 15 14 6 11 Thank you so much. Continue reading...