I have input data stored in a dataframe [16,60000] with columns corresponding to different time. I'm trying to calculate the integral along two different axis using np.trapz at every timestep. I tried : classical loop + append to list classical loop + storing to an array list comprehension but I could not see major improvements. How could I speed up this script ? Here is a minimal snippet: import numpy as np import pandas as pd import time time_start = time.time() # Read data df_data = pd.DataFrame(np.random.randn(16, 60000)) x_values = np.array([0. , 0.03, 0.1 , 0.2 , 0.3 , 0.4 , 0.5 , 0.6 , 0.7 , 0.8 , 0.9 , 0.85, 0.7 , 0.5 , 0.2 , 0.05]) x_values2 = np.array([0. , 0.043, 0.083, 0.114, 0.13 , 0.134, 0.124, 0.102, 0.078, 0.056, 0.03 , -0.006, -0.02 , -0.055, -0.069, -0.042]) # Get sample characteristics Ns = df_data.shape[1] times = range(Ns) lt_data = [df_data.iloc[:,i] for i in times] a = np.array([-np.trapz(y=data, x=x_values) for data in lt_data]) b = np.array([np.trapz(y=data, x=x_values2) for data in lt_data]) time_end = time.time() elapsed = time_end - time_start print(f'Elapsed: {elapsed:.1f}s') Continue reading...