[Python] regex replace numbers between to characters

I have a string 'manual__2025-04-08T11:37:13.757109+00:00' and I want 'manual__2025-04-08T11_37_13_00_00'

I know how to substitute the : and + using

'manual__2025-04-08T11:37:13.757109+00:00'.replace(':','_').replace('+','_')


but I also want to get rid of the numbers between the two characters '.' and '+'.

I'm using python.

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