I am using python to interogate a USB Serial device (a nino tnc) I have 3 separate systems. Linux ubuntu with no issues Linux Rpi with no issues Windows 10 with issues. As it responds correctly in the 1st 2 systems I don't think it is a hardware issue. Windows 10 64 bit. Simple Test python code import serial port = serial.Serial('COM3',57000) # open serial port print(port.name) # check which port was really used port.write(b'hello') # write a string port.close() # close port Error message import serial ModuleNotFoundError: No module named 'serial' Check my system C:\\Users\\djcle\>python --version Python 3.9.6 C:\\Users\\djcle\>pip --version pip 25.0.1 from c:\\users\\djcle\\appdata\\local\\programs\\python\\python39\\lib\\site-packages\\pip (python 3.9) C:\\Users\\djcle\>pip list modules Package Version ----------------- future 1.0.0 iso8601 2.1.0 pip 25.0.1 pyserial 3.5 PyYAML 6.0.2 serial 0.0.97 setuptools 56.0.0 pyserial is there ok. I thought serial was part of pyserial? this works fine import sys print("sys version") print(sys.version) print() print("sys.path") print(sys.path)` Output below ====================================================== RESTART: G:/Radio/Packet_APRS/tnc-tools/tnc-tools/SERIALTEST2.py ====================================================== sys version 3.11.3 (tags/v3.11.3:f3909b8, Apr 4 2023, 23:49:59) \[MSC v.1934 64 bit (AMD64)\] sys.path \['G:/Radio/Packet_APRS/tnc-tools/tnc-tools', 'G:\\Radio\\Packet_APRS\\tnc-tools\\tnc-tools', 'C:\\Users\\djcle\\AppData\\Local\\Programs\\Python\\Python311\\python311.zip', 'C:\\Users\\djcle\\AppData\\Local\\Programs\\Python\\Python311\\DLLs', 'C:\\Users\\djcle\\AppData\\Local\\Programs\\Python\\Python311\\Lib', 'C:\\Users\\djcle\\AppData\\Local\\Programs\\Python\\Python311', 'C:\\Users\\djcle\\AppData\\Local\\Programs\\Python\\Python311\\Lib\\site-packages'\] Checking where pyserial is installed C:\Users\djcle>pip install pyserial Requirement already satisfied: pyserial in c:\users\djcle\appdata\local\programs\python\python39\lib\site-packages (3.5) Now on my two Linux machines above works fine. I have been trying to sort this out for 2 days. Help please! What I have tried is documented in main message. Perhaps somebody has encountered and solved this issue? Continue reading...