I have book1.xlsx and online_retail.xlsx in the same folder. Tried to load the Excel file into DataFrame using Pandas however it returned an error FileNotFoundError: [Errno 2] No such file or directory: 'online_retail.xlsx'. How to set Python in Excel current folder? Tried import pandas as pd df = pd.read_excel('online_retail.xlsx') Got FileNotFoundError: [Errno 2] No such file or directory: 'online_retail.xlsx' Tried import pandas as pd df = pd.read_excel(r'C:\Dev\Python\online_retail.xlsx') Got FileNotFoundError: [Errno 2] No such file or directory: '"C:\\Dev\\Python\\online_retail.xlsx"' Tried import os current_working_directory = os.getcwd() print(current_working_directory) Got /app Tried import os os.chdir("C:\Dev\Python") Got FileNotFoundError: [Errno 2] No such file or directory: 'C:\\Dev\\Python' <br> Continue reading...