I am trying to write automated code in Python that will first list all available serial com ports on a PC (in Windows 10) and then checks which is active (open). import serial active_ports = [port.device for port in serial.tools.list_ports.comports()] print(active_ports) # and then put in a for loop to test each ser = serial.Serial(active_ports, 9600, timeout=1) But after last line it is just stuck there. But when I specify the port number I get this: import serial ser = serial.Serial("COM5", 9600, timeout=1) Traceback (most recent call last): File "<pyshell#7>", line 1, in <module> ser = serial.Serial("COM5", 9600, timeout=1) File "C:\Users\ghoura\AppData\Local\Packages\PythonSoftwareFoundation.Python.3.10_qbz5n2kfra8p0\LocalCache\local-packages\Python310\site-packages\serial\serialwin32.py", line 33, in __init__ super(Serial, self).__init__(*args, **kwargs) File "C:\Users\ghoura\AppData\Local\Packages\PythonSoftwareFoundation.Python.3.10_qbz5n2kfra8p0\LocalCache\local-packages\Python310\site-packages\serial\serialutil.py", line 244, in __init__ self.open() File "C:\Users\ghoura\AppData\Local\Packages\PythonSoftwareFoundation.Python.3.10_qbz5n2kfra8p0\LocalCache\local-packages\Python310\site-packages\serial\serialwin32.py", line 64, in open raise SerialException("could not open port {!r}: {!r}".format(self.portstr, ctypes.WinError())) serial.serialutil.SerialException: could not open port 'COM5': OSError(22, 'The semaphore timeout period has expired.', None, 121) Continue reading...