Any help with this issue is much appreciated. Goal: Connect Django to MSSQL server using FreeTDS. I'm using a Debian x64 box. Problem: When trying to make a connection I get the following. ('01000', "[01000] [unixODBC][Driver Manager]Can't open lib 'libtdsodbc.so' : file not found (0) (SQLDriverConnect)") My /etc/odbcinst.ini is configured as followed [FreeTDS] Description = FreeTDS driver = /usr/lib/x86_64-linux-gnu/odbc/libtdsodbc.so setup = /usr/lib/x86_64-linux-gnu/odbc/libtdsS.so The files do exist and have 777 access for testing. The connection string is like cnxn = pyodbc.connect( 'DRIVER={FreeTDS};SERVER=' + server + ';PORT=1443;DATABASE=' + database + ';UID=' + username + ';PWD=' + password) cursor = cnxn.cursor() My odbcinst -j reads (since adding symlink) unixODBC 2.3.1 DRIVERS............: /usr/local/etc/odbcinst.ini SYSTEM DATA SOURCES: /usr/local/etc/odbc.ini FILE DATA SOURCES..: /usr/local/etc/ODBCDataSources USER DATA SOURCES..: /root/.odbc.ini SQLULEN Size.......: 8 SQLLEN Size........: 8 SQLSETPOSIROW Size.: 8 Continue reading...