Using pip3 to install a package in a virtualenv causes the package to be installed in the global site-packages folder instead of the one in the virtualenv folder. Here's how I set up Python3 and virtualenv on OS X Mavericks (10.9.1): I installed Python3 using Homebrew: ruby -e "$(curl -fsSL https://raw.github.com/Homebrew/homebrew/go/install)" brew install python3 --with-brewed-openssl Changed the $PATH variable in .bash_profile; added the following line: export PATH=/usr/local/bin:$PATH Running which python3 returns /usr/local/bin/python3 (after restarting the shell). Note: which python3 still returns /usr/bin/python though. Installed virtualenv using pip3: pip3 install virtualenv Next, create a new virtualenv and activate it: virtualenv testpy3 -p python3 cd testpy3 source bin/activate Note: if I don't specify -p python3, pip will be missing from the bin folder in the virtualenv. Running which pip and which pip3 both return the virtualenv folder: /Users/kristof/VirtualEnvs/testpy3/bin/pip3 Now, when I try to install e.g. Markdown using pip in the activated virtualenv, pip will install in the global site-packages folder instead of the site-packages folder of the virtualenv. pip install markdown Running pip list returns: Markdown (2.3.1) pip (1.4.1) setuptools (2.0.1) virtualenv (1.11) Contents of /Users/kristof/VirtualEnvs/testpy3/lib/python3.3/site-packages: __pycache__/ _markerlib/ easy_install.py pip/ pip-1.5.dist-info/ pkg_resources.py setuptools/ setuptools-2.0.2.dist-info/ Contents of /usr/local/lib/python3.3/site-packages: Markdown-2.3.1-py3.3.egg-info/ __pycache__/ easy-install.pth markdown/ pip-1.4.1-py3.3.egg/ setuptools-2.0.1-py3.3.egg setuptools.pth virtualenv-1.11-py3.3.egg-info/ virtualenv.py virtualenv_support/ As you can see, the global site-packages folder contains Markdown, the virtualenv folder doesn't. Note: I had Python2 and Python3 installed before on a different VM (followed these instructions) and had the same issue with Python3; installing packages in a Python2 based virtualenv worked flawlessly though. Any tips, hints, … would be very much appreciated. Continue reading...