I have a pandas dataframe ('df3') which columns I would like to rename.It is a subset of another dataframe, and I'm working in a jupyter notebook. Getting all infos from the dataframe structure: df3.info() <class 'pandas.core.frame.DataFrame'> RangeIndex: 29 entries, 104 to 132 Data columns (total 15 columns): # Column Non-Null Count Dtype --- ------ -------------- ----- 0 Zählung in 28 non-null object 1 Unnamed: 17 29 non-null object 2 Unnamed: 18 29 non-null object 3 Unnamed: 19 29 non-null object 4 Unnamed: 20 29 non-null object 5 Unnamed: 21 29 non-null object 6 Unnamed: 40 29 non-null object 7 Unnamed: 41 29 non-null object 8 Unnamed: 42 29 non-null object 9 Unnamed: 43 28 non-null object 10 Unnamed: 44 28 non-null object 11 Unnamed: 63 29 non-null object 12 Unnamed: 64 29 non-null object 13 Unnamed: 65 29 non-null object 14 Unnamed: 66 28 non-null object dtypes: object(15) memory usage: 3.5+ KB The columns need to be renamed by their index, so I create a dict with the index as keys and the new names as values: col_names= {0:'Zeit', 1:'ZU_PKW', 2: 'ZU_LKW1', 3: 'ZU_LKW2', 4: 'ZU_SV', 5: 'ZU_SV%', 6:'AB_PKW', 7: 'AB_LKW1', 8: 'AB_LKW2', 9: 'AB_SV', 10: 'AB_SV%', 11:'ALL_PKW', 12: 'ALL_LKW1', 13: 'ALL_LKW2', 14: 'ALL_SV' } I tried to rename the columns with all options using the 'rename'-function: 1. Create a new dataframe with renamed columns without using inplace=True df4 = df3.rename(index=col_names) Result: no error, but the columns are not renamed 2. Create a new dataframe with renamed columns by using inplace=True df4 = df3.rename(index={col_names, inplace = True) Result: Error: A value is trying to be set on a copy of a slice from a DataFrame And the resulting df is None. 3. Change the dataframe directly by using inplace=True df3.rename(index={col_names, inplace = True) Result: `Error: A value is trying to be set on a copy of a slice from a DataFrame and the df3 stays unchanged. 4. Specifying also axis=1 df3.rename(index={col_names, inplace = True) Returns TypeError: Cannot specify both 'axis' and any of 'index' or 'columns' I feel I'm running out of options. What am I doing wrong? Could it have something to do with working in the jupyter notebook environment? Continue reading...