I have a BytesIO file-like object, containing a CSV. I want to read it into a Pandas dataframe, without writing to disk in between. MWE In my use case I downloaded the file straight into BytesIO. For this MWE I'll have a file on disk, read it into BytesIO, then read that into Pandas. The disk step is just to make a MWE. file.csv a,b 1,2 3,4 Script: import pandas as pd from io import BytesIO bio = BytesIO() with open('file.csv', 'rb') as f: bio.write(f.read()) # now we have a BytesIO with a CSV df = pd.read_csv(bio) Result: Traceback (most recent call last): File "pandas-io.py", line 8, in <module> df = pd.read_csv(bio) File "/home/ec2-user/.local/lib/python3.6/site-packages/pandas/io/parsers.py", line 685, in parser_f return _read(filepath_or_buffer, kwds) File "/home/ec2-user/.local/lib/python3.6/site-packages/pandas/io/parsers.py", line 457, in _read parser = TextFileReader(fp_or_buf, **kwds) File "/home/ec2-user/.local/lib/python3.6/site-packages/pandas/io/parsers.py", line 895, in __init__ self._make_engine(self.engine) File "/home/ec2-user/.local/lib/python3.6/site-packages/pandas/io/parsers.py", line 1135, in _make_engine self._engine = CParserWrapper(self.f, **self.options) File "/home/ec2-user/.local/lib/python3.6/site-packages/pandas/io/parsers.py", line 1917, in __init__ self._reader = parsers.TextReader(src, **kwds) File "pandas/_libs/parsers.pyx", line 545, in pandas._libs.parsers.TextReader.__cinit__ pandas.errors.EmptyDataError: No columns to parse from file Note that this sounds like a similar problem to the title of this post, but the error messages are different, and that post has the X-Y problem. Continue reading...