Here is a hypothetical scenario with multiindex dataframes in pandas. Trying to merge them will result in an error. Do I have to do reset_index() on either dataframe to make this work? arrays = [['bar', 'bar', 'baz', 'baz', 'foo', 'foo', 'qux', 'qux'], ['one', 'two', 'one', 'two', 'one', 'two', 'one', 'two']] tuples = list(zip(*arrays)) index1 = pd.MultiIndex.from_tuples(tuples, names=['first', 'second']) index2 = pd.MultiIndex.from_tuples(tuples, names=['third', 'fourth']) s1 = pd.DataFrame(np.random.randn(8), index=index1, columns=['s1']) s2 = pd.DataFrame(np.random.randn(8), index=index2, columns=['s2']) Attempted merges: s1.merge(s2, how='left', left_index=True, right_index=True) Editor's note: The error for this one was most likely ValueError: cannot join with no overlapping index names. Tested with Pandas 2.2.3 s1.merge(s2, how='left', left_on=['first', 'second'], right_on=['third', 'fourth']) Editor's note: It's not clear what error occurred here. If you know, please add it. Continue reading...