In my application, Python interacts with two Arduino Mega boards for hundreds of thousands of cycles. Since the PC is far from the chambers, the cables have to be long, and that is why I use active USB A-A axtension cables. This active USB 2.0 [AM-AF] extension cable has been working consistently for me, and I am happy with it. However, when I used two of these cables to my PC, they stop working (one of the Arduinos momentarily disconnects and re-connects under the same port name). My suspicion was that the cables are drawing too much current from the USB ports. So, switched to an externally-powered active USB 3.0 [AM-AF] cable along with the self-powered USB 2.0 [AM-AF] one. Surprise, surprise, it didn't work. The active USB [AM-AF] extension cables were used in combination with a 10-feet USB 2.0 [AM-BM]. That 10-feet cable works fine by itself and gives me stable connection for as long as I need that Arduino to stay connected. To avoid cable combinartion, I even switched to a long active [AM-BM] cable, and that did not work when used with the other active cable. Here is the error message returned by Python, arduino_serial_resource.reset_input_buffer(); ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ File "/usr/lib/python3/dist-packages/serial/serialposix.py", line 683, in reset_input_buffer self._reset_input_buffer() File "/usr/lib/python3/dist-packages/serial/serialposix.py", line 677, in _reset_input_buffer termios.tcflush(self.fd, termios.TCIFLUSH) termios.error: (5, 'Input/output error') My PC operates on Ubuntu 24.04 LTS. Could anyone please help me investigate this methodically? Continue reading...