The integral is Where the variables follow the following distribution: Thus, the integral becomes: Now, my code in python is to integrate the expression with \(W_{1:3}\) being \(1,2,3\) respectively, \(r_1 = 0\), \(v\), which is the variance is \(1\), and the time constant \(tau\) being \(1\), I want to estimate roots of the derivative to find \(D\) as following: import sympy as sp import math w_n = [0,1,2] r_1 = sp.Symbol("r_1") r_2 = sp.Symbol("r_2") r_3 = sp.Symbol("r_3") r_n = [0, r_2,r_3] D = sp.Symbol("D") v = sp.Symbol("v") t = sp.Symbol("t") def expo_power(i=0,t=t,D=D,v=v): return ((((w_n - r_n) ** 2)/(2 * v)) + (((r_n - r_n[i-1]) ** 2)/(4 * D * t))) def expo_power_sum(lower_bound = 2, upper_bound=3,t=t,D=D,v=v): f = 0 for i in range(lower_bound,upper_bound): f += expo_power(i-1,t=t,D=D,v=v) return f def P_w_n_P_r_n(i=0,v=v,D=D,t=t): return (1/(8 * (sp.pi ** 2) * D * t * v)) \ * sp.exp(-expo_power_sum(lower_bound=2,upper_bound=3,t=t,D=D,v=v)) def P_w_i_r_i(i = 0, v=v): return (1/(sp.sqrt(2 * sp.pi * v))) \ * sp.exp(-((w_n - r_n) ** 2/(2 * v))) def normal_dist(x =0, m = r_n[0], v =v): return (1/(sp.sqrt(2 * sp.pi * v))) \ * sp.exp(-(((x - m) ** 2)/(2 * v))) def integrand(v = v,t=t,lower = 2): f = P_w_n_P_r_n(i=lower,v=v,D=D,t=t) sp.pprint(f) f = f * P_w_i_r_i(v=v) f = f * normal_dist(x=r_n[0],v=v) return f def integrate(v=v,t=t, lower_bound = -sp.oo, upper_bound= sp.oo): function = integrand(v=v,t=t) integral_1 = sp.integrate(function, (r_1, lower_bound, upper_bound)).evalf() sp.pprint(integral_1) integral_2 = sp.integrate(integral_1, (r_3, lower_bound, upper_bound)).evalf() sp.pprint(integral_2) integral_3 = sp.integrate(integral_2, (r_2, lower_bound, upper_bound)).evalf() num = sp.N(integral_3) print(num) #sp.pprint(integral_3) deriv = sp.diff(num, D) sol = sp.solve(deriv, D) sp.pprint(sol) integrate(v=1,t=1,lower_bound=-1000,upper_bound=1000) Now, the solution displayed is the ratio between two unevaluated integrals. note that and t in the python code is (tau) and we're finding the roots of the derivative with respect to (D) after marginalizing out (r_1,r_2,r_3), the integral is not being evaluated, particularly, for (r_2) Continue reading...