I am wondering the best way to slice a multi-index, using another index, where the other index is a subset of the main multi-index. np.random.seed(1) dict_data_russian = {'alpha':[1,2,3,4,5,6,7,8,9],'beta':['a','b','c','d','e','f','g','h','i'],'gamma':['r','s','t','u','v','w','x','y','z'],'value_r': np.random.rand(9)} dict_data_doll = {'beta':['d','e','f'],'gamma':['u','v','w'],'dont_care': list('PQR')} df_russian = pd.DataFrame(data=dict_data_russian) df_russian.set_index(['alpha','beta','gamma'],inplace=True) df_doll = pd.DataFrame(data=dict_data_doll) df_doll.set_index(['beta','gamma'],inplace=True) print df_russian print df_doll.head() Which yields: value_r alpha beta gamma 1 a r 0.4170 2 b s 0.7203 3 c t 0.0001 4 d u 0.3023 5 e v 0.1468 6 f w 0.0923 7 g x 0.1863 8 h y 0.3456 9 i z 0.3968 dont_care beta gamma d u P e v Q f w R How best to use the index in df_doll to slice df_russian, on levels beta & gamma, in order to the following output? value_r alpha beta gamma 4 d u 0.3023 5 e v 0.1468 6 f w 0.0923 Continue reading...