I wanted to make a Flask server that receives data from an android app, and then sends data over serial to an arduino connected via USB. However, I can't seem to be able to access the COM port where the arduino is connected. from flask import Flask from flask_restful import Api, Resource, reqparse import serial # Initialize serial streams serCam = serial.Serial('COM3', baudrate=9600, timeout=1) if not serCam.isOpen(): serCam.open() app = Flask(__name__) api = Api(app) ## Here there are flask requests... if __name__ == "__main__": app.run(debug=True) And the error is this one: "serial.serialutil.SerialException: could not open port 'COM3': PermissionError(13, 'Access is denied.', None, 5)" I have checked that I am trying to connect to the correct port using the arduino terminal and using the same serial related code in another script. I did not forget to close any other serial connections. I also ran the python script with administrator rights, as I read that on windows the COM port privileges are sometimes locked to normal users on windows, but it still doesn't work as I believe Flask starts a subprocess that no longer has admin privileges. So is there any way to grant COM port access to a flask application without granting all the root privileges? Continue reading...