I've been using Pythonnet for quite some time but always against .NET Framework 4.* With the recent release of .NET 5.0 I wanted to migrate my projects but I could not make it work for non-Framework versions (e.g. .NET Core 2.0, .NET Core 3.0, .NET 5.0) Here is a very simple test I ran with .NET Framework 4.5: namespace TestNet { public class Dummy { private string _name; public Dummy(string name) { _name = name; } public string Hello(string name) { return $"Hello {name}, my name is {_name}"; } } } This produces TestNet.dll then I run the following Python code: >>> import clr >>> clr.AddReference("TestNet") <System.Reflection.RuntimeAssembly object at 0x000001899ACFABB0> >>> from TestNet import Dummy >>> d = Dummy("Bob") >>> d.Hello("John") 'Hello John, my name is Bob' So everything works fine. Now, the exact same C# code but targeting .NET Core or .NET 5.0 will give me: >>> import clr >>> clr.AddReference("TestNet") <System.Reflection.RuntimeAssembly object at 0x00000122AF0DABB0> >>> from TestNet import Dummy Traceback (most recent call last): File "<stdin>", line 1, in <module> ModuleNotFoundError: No module named 'TestNet' My understanding is they are using CoreClr and not CLR and from Pythonnet website (https://pythonnet.github.io/): Python.NET (pythonnet) is a package that gives Python programmers nearly seamless integration with the .NET 4.0+ Common Language Runtime (CLR) Does anyone know if CoreClr is supported? Thanks! Env: Python 3.8/Windows 10 Continue reading...