I have three lambda functions: boss, worker1, worker2. When using boto3.client.invoke I am able to call worker1 from boss. These two are in the same region. worker2 is in a separate region. When attempting to call worker2 from boss the following error returns: "An error occurred (ResourceNotFoundException) when calling the Invoke operation: Functions from 'us-east-1' are not reachable in this region ('us-west-2')" . boss has an execution role with the following permission: { "Version": "2012-10-17", "Statement": [ { "Action": [ "lambda:InvokeFunction" ], "Effect": "Allow", "Resource": "arn:aws:lambda:*:*:*" } ] } Please help clarify how permissions need to be conveyed for this to work. Thanks Edit: master and worker1 are in us-west-2 and worker1 is in us-east-1. Here is the code used to invoke worker from master: def lambda_handler(event, context): function_name = "arn:aws:lambda:us-east-1-...:function:worker_2" lambda_client = boto3.client('lambda') payload = json.dumps({"body-json": "payload string") response = lambda_client.invoke( FunctionName = function_name, Payload = payload ) response_payload = response['Payload'].read() response_arr = json.loads(response_payload) return response_arr['answer'] Continue reading...