I know how to play a wav file with python_vlc, e.g (here to play an audio stream) import vlc instance=vlc.Instance('--input-repeat=-1','--fullscreen') player=instance.media_player_new() url="my url" media=instance.media_new(url) player.set_media(media) player.play() but I didn't find any command to play it in mono mode. Any help appreciated. I've asked the support of my hardware and searched among stackoverflow questions. Continue reading...