I am parsing datetime values as follows: df['actualDateTime'] = pd.to_datetime(df['actualDateTime']) How can I convert this datetime objects to milliseconds? I didn't see mention of milliseconds in the doc of to_datetime. Update (Based on feedback): This is the current version of the code that provides error TypeError: Cannot convert input to Timestamp. The column Date3 must contain milliseconds (as a numeric equivalent of a datetime object). import pandas as pd import time s1 = {'Date' : ['2015-10-20T07:21:00.000','2015-10-19T07:18:00.000','2015-10-19T07:15:00.000']} df = pd.DataFrame(s1) df['Date2'] = pd.to_datetime(df['Date']) t = pd.Timestamp(df['Date2']) df['Date3'] = time.mktime(t.timetuple()) print df Continue reading...