I am reading a csv file into pandas. This csv file consists of four columns and some rows, but does not have a header row, which I want to add. I have been trying the following: Cov = pd.read_csv("path/to/file.txt", sep='\t') Frame = pd.DataFrame([Cov], columns = ["Sequence", "Start", "End", "Coverage"]) Frame.to_csv("path/to/file.txt", sep='\t') But when I apply the code, I get the following Error: ValueError: Shape of passed values is (1, 1), indices imply (4, 1) What exactly does the error mean? And what would be a clean way in python to add a header row to my csv file/pandas df? Continue reading...