I'm working on a project which needs to call python script in c#. The fact is that I'm familiar with python, but not c#, not at all. As I have learnt, there are basically two options: Iron and Python.net, you can check it out here https://www.youtube.com/watch?v=oG5mmElsWJM&lc=UgzwcXvIteCqTjmHl2N4AaABAg.9Ls9q7VkDdc9MCYIPfOW0d. I'm struggling with python.net now. I've tried to call a simple multiply function (e.g. a * b), works perfect. But when I turned to image data, there pops up an error called "The type initializer for 'Delegates' threw an exception." The python script I used is: import cv2 import numpy as np def binarise(image): ret, img_output = cv2.threshold(image,100,255,cv2.THRESH_BINARY) return img_output The c# I tried is: if (greyImage1 != null) { try { var pythonPath = @"C:\Users\Admin\anaconda3"; Environment.SetEnvironmentVariable("PATH", $@"{pythonPath};" + Environment.GetEnvironmentVariable("PATH")); Environment.SetEnvironmentVariable("PYTHONHOME", pythonPath); Environment.SetEnvironmentVariable("PYTHONPATH ", $@"{pythonPath}\Lib"); string scriptFile = "myfunction.py"; string pythonCode = ""; using (var streamReader = new StreamReader(scriptFile, Encoding.UTF8)) { pythonCode = streamReader.ReadToEnd(); } using (Py.GIL()) { var scope = Py.CreateScope(); scope.Exec(pythonCode); greyImage1 = (scope as dynamic).binarise(greyImage1); pictureBox1.Image = (System.Drawing.Image)greyImage1; this.Cursor = Cursors.Default; } } catch (Exception ex) { messageL.Text = ex.Message; } } Anyone got any ideas? Appreciate your time and help. Continue reading...