In excel sheet i want to compare the 2 columns. The column names like file_1 and file_2. by using these 2 cols want to create the another col like 'diff' by using excel formula [countifs]. In case , if file_1 and file_2 column records matched it should be 0 (Zero) in diff column otherwise it should be 1. But, i am not as excepted result. Could please help anyone. here is my inputs : file_1 file_2 G G A B C F E H A C H E Output Dataframe : file_1 file_2 diff G G 0 A B 1 C F 1 E H 0 A C 0 H E 0 Sample code : df = pd.read_excel('file1.xlsx') df1 = df[df['file_1'].isin(df['file_2'])] df['diff'] = df1 print(df) Continue reading...