I have tried to set either PYO3_CROSS_LIB_DIR or PYO3_PYTHON, both from terminal or in my build.rs but I keep having this /install as prefix everywhere and consequently my bin is not working. I'm using pyenv for managing python versions mac os 15.3.2 on Apple M2. a venv managed by uv. pyo3 = { version = "0.23.4" } my builds.rs looks like use dotenvy::dotenv_override; use std::env; fn main() { if let Err(err) = dotenv_override() { eprintln!("Warning: Failed to load .env file: {err}"); } // Build time dependencies if let Ok(lib_path) = env::var("LIBRARY_PATH") { println!("cargo:rustc-link-search={lib_path}"); println!("cargo:rerun-if-env-changed=LIBRARY_PATH"); } // Link time dependencies if let Ok(ld_library_path) = env::var("LD_LIBRARY_PATH") { println!("cargo:rustc-link-arg=-Wl,-rpath,{ld_library_path}"); println!("cargo:rerun-if-env-changed=LD_LIBRARY_PATH"); } if let Ok(dyld_library_path) = env::var("DYLD_LIBRARY_PATH") { println!("cargo:rustc-link-arg=-Wl,-rpath,{dyld_library_path}"); println!("cargo:rerun-if-env-changed=DYLD_LIBRARY_PATH"); } } when I run PYO3_PRINT_CONFIG=1 cargo b I see -- PYO3_PRINT_CONFIG=1 is set, printing configuration and halting compile -- implementation=CPython version=3.10 shared=true abi3=false lib_name=python3.10 lib_dir=/install/lib executable=/Users/clementwalter/Documents/kkrt-labs/keth/.venv/bin/python pointer_width=64 build_flags= python_framework_prefix= suppress_build_script_link_lines=false so here I already see this /install and I don't know where it comes from. once built, using otool I see $ otool -L target/release/keth-run target/release/keth-run: /install/lib/libpython3.10.dylib (compatibility version 3.10.0, current version 3.10.0) /usr/lib/libiconv.2.dylib (compatibility version 7.0.0, current version 7.0.0) /usr/lib/libSystem.B.dylib (compatibility version 1.0.0, current version 1351.0.0) if then I try to run, it fails dyld[41034]: Library not loaded: /install/lib/libpython3.10.dylib Referenced from: <7D8217ED-521B-3870-B777-1DAFA99B7940> /Users/clementwalter/Documents/kkrt-labs/keth/target/debug/keth-run Reason: tried: '/install/lib/libpython3.10.dylib' (no such file) if I export the DYLD path export DYLD_LIBRARY_PATH=$HOME/.local/share/uv/python/cpython-3.10.15-macos-aarch64-none/lib it actually starts but raises and again I see all these /install prefixes Could not find platform independent libraries <prefix> Could not find platform dependent libraries <exec_prefix> Consider setting $PYTHONHOME to <prefix>[:<exec_prefix>] Python path configuration: PYTHONHOME = (not set) PYTHONPATH = (not set) program name = 'python3' isolated = 0 environment = 1 user site = 1 import site = 1 sys._base_executable = '/Users/clementwalter/Documents/kkrt-labs/keth/target/debug/keth-run' sys.base_prefix = '/install' sys.base_exec_prefix = '/install' sys.platlibdir = 'lib' sys.executable = '/Users/clementwalter/Documents/kkrt-labs/keth/target/debug/keth-run' sys.prefix = '/install' sys.exec_prefix = '/install' sys.path = [ '/install/lib/python310.zip', '/install/lib/python3.10', '/install/lib/lib-dynload', ] Fatal Python error: init_fs_encoding: failed to get the Python codec of the filesystem encoding Python runtime state: core initialized ModuleNotFoundError: No module named 'encodings' Continue reading...