I am working on a semantic segmentation problem where I have an input x ( CT image) to a deep learning model of shape (batch_size,1,256,256) and an output of shape (batch_size,2,256,256) where the first channel represents an output mask (bone mask), and the second represents a second output mask ( lesion mask). I am using a combined loss function for every channel output , which is a combination of wighted BCE and soft dice loss both focussing on the foreground pixels : class Custom_Loss(tf.keras.losses.Loss): def __init__(self,w1 = 0.3, w2 = 0.7 , w3 = 0.4, w4 = 0.6, w5 = 1.6 , reduction="sum_over_batch_size" ): """ w1 : weight for the bone loss contribution to the total loss. w2 : Weight for the lession loss contribution to the total loss. w3 : Weight for the soft dice loss contribution to the combined loss. w4 : Weight for the BCE contribution to the combined loss. w5: Weight for the foreground pixels in the BCE loss """ self.w1 = w1 self.w2 = w2 self.w3 = w3 self.w4 = w4 self.w5 = w5 self.reduction = reduction super().__init__(reduction = reduction) def bce(self,y_true, y_pred): epsilon = 1e-8 # Add small epsilon to avoid log(0) # Compute the total number of pixels N = y_true.shape[1] * y_true.shape[2] # Compute the BCE loss per image bce_loss = (-1 / N) * tf.reduce_sum((self.w5 *y_true * tf.math.log(y_pred + epsilon)) + ((1 - y_true) * tf.math.log(1 - y_pred + epsilon)),axis = (1,2)) # Average the loss over the batch #bce_loss = tf.reduce_mean(bce_loss) return bce_loss def soft_dice_loss(self,y_true, y_pred): epsilon = 1e-8 # Add small epsilon to avoid division by zero # Calculate the numerator and denominator numerator_dice_coef= 2 * tf.reduce_sum(y_true * y_pred, axis=(1, 2)) + epsilon den_dice_coef = (tf.reduce_sum(y_true * y_true, axis=(1, 2))) + (tf.reduce_sum(y_pred * y_pred, axis=(1, 2))) + epsilon # Dice coefficient per image in the batch dice_coef = numerator_dice_coef / den_dice_coef # Average Dice coefficient over the batch #mean_dice_coef = tf.reduce_mean(dice_coef) return 1 - dice_coef def combined_loss(self, y_true, y_pred): loss = (self.w3 * self.soft_dice_loss(y_true, y_pred) ) + (self.w4 * self.bce(y_true, y_pred)) return loss def call(self, y_true, y_pred): bone_pred = y_pred [:,0,:,:] lesion_pred = y_pred [:,1,:,:] bone_ground_truth = y_true [:,0,:,:] lesion_ground_truth = y_true [:,1,:,:] #loss = (self.w1 * self.combined_loss(bone_ground_truth, bone_pred ) ) + (self.w2 * self.combined_loss(lession_ground_truth, lession_pred) ) # Compute combined loss for bone and lesion masks bone_loss = self.combined_loss(bone_ground_truth, bone_pred) # Shape: (batch_size,) lesion_loss = self.combined_loss(lesion_ground_truth, lesion_pred) # Shape: (batch_size,) # Total loss per sample # Use tf.multiply for weighted sum weighted_bone_loss = tf.multiply(self.w1, bone_loss) # Shape: (batch_size,) weighted_lesion_loss = tf.multiply(self.w2, lesion_loss) # Shape: (batch_size,) # Add weighted losses total_loss = weighted_bone_loss + weighted_lesion_loss # Shape: (batch_size,) # Store loss components for logging #self.last_bone_loss = tf.reduce_mean(bone_loss) #self.last_lesion_loss = tf.reduce_mean(lesion_loss) return total_loss I am following the keras documentation where the call function returns the loss per sample. Now I wrote a custom callback to log the validation loss components ( for every mask, bone and lesion) as well as the total loss, as follows : # Callback for logging loss components at the end of each epoch for the validation data class LossLoggerCallback(tf.keras.callbacks.Callback): def __init__(self, loss_fn, validation_data): """ Callback to log loss components for validation data at the end of each epoch. Args: loss_fn: Custom loss function (instance of `CustomLoss`). validation_data: Validation dataset (can be a tf.data.Dataset). """ super().__init__() self.loss_fn = loss_fn self.validation_data = validation_data def on_epoch_end(self, epoch, logs=None): # Initialize lists to accumulate losses total_losses = [] bone_losses = [] lesion_losses = [] # Initialize a counter to keep track of the total number of samples total_samples = 0 # Iterate over all batches in the validation data for x_val, y_val in self.validation_data: batch_size = x_val.shape[0] # Get the batch size # Make predictions y_pred = self.model.predict(x_val, verbose=0) # Extract bone and lesion predictions and ground truths bone_pred = y_pred[:, 0, :, :] lesion_pred = y_pred[:, 1, :, :] bone_gt = y_val[:, 0, :, :] lesion_gt = y_val[:, 1, :, :] # Compute combined loss for bone and lesion (this gives a batch-wise loss) bone_loss = self.loss_fn.combined_loss(bone_gt, bone_pred) # Shape: (batch_size,) lesion_loss = self.loss_fn.combined_loss(lesion_gt, lesion_pred) # Shape: (batch_size,) # Apply weighting as in `call` weighted_bone_loss = tf.multiply(self.loss_fn.w1, bone_loss) # Shape: (batch_size,) weighted_lesion_loss = tf.multiply(self.loss_fn.w2, lesion_loss) # Shape: (batch_size,) # Total loss per sample in the batch total_loss = weighted_bone_loss + weighted_lesion_loss # Shape: (batch_size,) # Accumulate batch-wise losses for averaging later total_losses.extend(total_loss.numpy()) # Add individual losses per sample bone_losses.extend(bone_loss.numpy()) # Add individual bone losses lesion_losses.extend(lesion_loss.numpy()) # Add individual lesion losses # Update total number of samples processed total_samples += batch_size # Compute the mean loss across the entire validation dataset mean_bone_loss = np.sum(bone_losses) / total_samples mean_lesion_loss = np.sum(lesion_losses) / total_samples mean_total_loss = np.sum(total_losses) / total_samples # Print the results for the current epoch print(f"Epoch {epoch + 1}: Validation Bone Loss = {mean_bone_loss:.4f}, " f"Validation Lesion Loss = {mean_lesion_loss:.4f}, " f"Validation Total Loss = {mean_total_loss:.4f}") The batch size used is 4 , so the shape of one batch in the validation is (4,2, 256,256) for y and for x it is (4,1,256,256) . Like you see in the custom loss class, i am using the reduction sum_over_batch_size. When I train the model in a multi-gpu environment : with strategy.scope(): loss_fn = Custom_Loss() # Initialize the model model= create_model() model.compile(optimizer=Adam(learning_rate=1e-4,beta_1 = 0.999, beta_2 = 0.999), loss= loss_fn, metrics=[IoU] ) val_loss_logger = LossLoggerCallback(loss_fn, validation_data=val_dataset) es = EarlyStopping(monitor='val_io_u', mode='max', verbose=1, patience=40) mc = ModelCheckpoint('/kaggle/working/best_model.keras', monitor='val_io_u', mode='max', verbose=1, save_best_only=True) # Train the model history = model.fit(x = train_dataset, batch_size= batch_size, validation_data = val_dataset, epochs= epochs, steps_per_epoch= steps_per_epoch, callbacks=[es,mc,val_loss_logger]) I get: Epoch 1/100 237/237 ━━━━━━━━━━━━━━━━━━━━ 0s 1s/step - io_u: 0.1837 - loss: 272.1821 Epoch 1: val_io_u improved from -inf to 0.00000, saving model to /kaggle/working/best_model.keras Epoch 1: Validation Bone Loss = 0.6672, Validation Lesion Loss = 0.6553, Validation Total Loss = 0.6589 237/237 ━━━━━━━━━━━━━━━━━━━━ 443s 1s/step - io_u: 0.1842 - loss: 271.8742 - val_io_u: 0.0000e+00 - val_loss: 83.1071 Epoch 2/100 237/237 ━━━━━━━━━━━━━━━━━━━━ 0s 1s/step - io_u: 0.3941 - loss: 56.6352 Epoch 2: val_io_u did not improve from 0.00000 Epoch 2: Validation Bone Loss = 0.5375, Validation Lesion Loss = 0.5063, Validation Total Loss = 0.5157 237/237 ━━━━━━━━━━━━━━━━━━━━ 339s 1s/step - io_u: 0.3941 - loss: 56.5627 - val_io_u: 0.0000e+00 - val_loss: 19.8229 Why Validation Total Loss returned by the callback is not equal to val_loss returned by keras. I think I have a misunderstanding regarding how keras calculates the loss using the reduction sum_over_batch_size. I want the loss returned by the callback to be identical to that calculated by keras. Continue reading...