[Python] Can I access a SharePoint using Python, when I have username and password with MFA?

Is there any mean to access a SharePoint using an interactive Python script? The conditions are the following:

• I have username/password for a user that can access the SharePoint online;
• There is MFA enabled;
• I can't register a new application on Azure, I have to stick only to the user.

I had a look to the Office365-REST-Python-Client library, but it seems like it is impossibile to do this without using a client_id (= application registered on Azure) or disabling MFA?

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