I have a code that works perfect in a Ubuntu system. This is just a minimal code based on it: import tkinter as Tk import tkFileDialog import ttk class AppGUI(Tk.Frame): def __init__(self, parent): self.ctrl = False self.parent = parent self.centerWindow() self.initGUI() self.plot() def initGUI(self): # Notebooks self.notebook = ttk.Notebook(self.parent) self.frame_one = Tk.Frame(self.notebook) # first page self.frame_two = Tk.Frame(self.notebook) # second page self.notebook.add(self.frame_one, text='Notebook 1') self.notebook.add(self.frame_two, text='Notebook 2') self.notebook.pack(side = Tk.TOP, fill="both", expand=True) # Realization frame self.out_frame = Tk.Frame(self.parent, bd=1, relief=Tk.SUNKEN) self.out_frame.pack(side=Tk.TOP, fill="both", expand=True) # Key events self.key() def centerWindow(self): w = 800 h = 800 sw = self.parent.winfo_screenwidth() sh = self.parent.winfo_screenheight() x = (sw - w)/2 y = (sh - h)/2 self.parent.geometry('%dx%d+%d+%d' % (w, h, x, y)) def key(self): # Key events def press(event): self.ctrl = True def release(event): self.ctrl = False self.parent.bind('<Control_L>', press) self.parent.bind('<KeyRelease-Control_L>', release) def plot1(self): f = plt.figure(figsize=(1, 1), dpi=300) c_plot1 = FigureCanvasTkAgg(f, master=self.frame_one) c_plot1.show() c_plot1.pack(side=Tk.LEFT, fill="both", expand=True) def onClickPlot1(event): if event.inaxes is not None: if self.ctrl: print "Control key pressed" # Do my stuff c_plot1.mpl_connect('button_press_event', onClickPlot1) def plot2(self): # Same stuff for plot 2 def plot(self): self.plot1() self.plot2() def main(): root = Tk.Tk() app = AppGUI(root) root.mainloop() if __name__ == '__main__': main() When I run thin in a Ubuntu machine, I can see that whatever Control key I press (left or right control) is correctly binded, as I see the print and the expected visual result. Running the same code in a Mac, on the other hand, I cannot see the print output and, of course, the expected result doesn't happens. I followed this document to perform the binding. I'm not trying to use the Mac Command key, just the regular left Control. Are there different biding codes for different systems? This doesn't make sense, but I can't find the problem. Continue reading...