I found an example of how to pass parameters using PythonNet, but I am not able to get it to trigger my Python code. Developing on VS 2022. I'm wanting to (first) create a subdirectory if is doesn't already exist. The path and directory should be passed from C#. protected void btnPythonTest_Click(object sender, EventArgs e) { // full path of python interpreter string python = @"C:\Users\User\AppData\Local\Programs\Python\Python312\python.exe"; // python app to call string myPythonApp = @"C:\OllamaDocs\MyTestPython.py"; // Paramters to send to Python (location of docs and Chroma for this user string OllamDocsPath = @"C:\OllamaDocs\100\1\"; string OllamaChromaFilename = "Chroma_100_1B"; try { System.Diagnostics.ProcessStartInfo myProcessStart = new System.Diagnostics.ProcessStartInfo(python); myProcessStart.UseShellExecute = true; myProcessStart.RedirectStandardOutput = false; // pass arguments to python script myProcessStart.Arguments = myPythonApp + " " + OllamDocsPath + " " + OllamaChromaFilename; System.Diagnostics.Process myProcess = new System.Diagnostics.Process(); myProcess.StartInfo = myProcessStart; myProcess.Start(); lblStatus.Text = myPythonApp + " Created " + OllamDocsPath + OllamaChromaFilename; } catch (Exception ex) { errorMessage = ex.Message; lblStatus.Text = errorMessage; } } // end PythonTest() My Python test script is located in the root of C: as follows (MyTestPython.py) import os import sys # Test Phase II #Get args from C# OllamaPath = sys.argv[0] OllamaChroma = sys.argv[1] # Define the directory for vector store persistence #persist_directory = "C:\\OllamaDocs\\100\\1\\chroma_db_100-1" persist_directory = OllamaPath # Check if the vector store already exists if not os.path.exists(persist_directory): print("Creating new Chroma Directory " + persist_directory) os.makedirs(persist_directory) else: # Load the existing Chroma vector store else: # Load the existing Chroma vector store print("path exists.") Continue reading...