Compiled binary is Intel-only, not native ARM64 from pip for venv. Interestingly I see that the created wheel is arm based: $ pip install mysqlclient Collecting mysqlclient Downloading mysqlclient-2.2.7.tar.gz (91 kB) Installing build dependencies ... done Getting requirements to build wheel ... done Preparing metadata (pyproject.toml) ... done Building wheels for collected packages: mysqlclient Building wheel for mysqlclient (pyproject.toml) ... done Created wheel for mysqlclient: filename=mysqlclient-2.2.7-cp312-cp312-macosx_11_0_arm64.whl size=75876 sha256=389bc727cf6a34eaeaa6811dedb8ca0de6739f5957b9908470833768809f0445 Stored in directory: /Users/daniel.yu/Library/Caches/pip/wheels/27/95/18/7f176fffd46629e710c04c810b9c4d7d4358fe7c96a7d2306d Successfully built mysqlclient Installing collected packages: mysqlclient Successfully installed mysqlclient-2.2.7 The catch is that at the end, the executable is intel-based. $ file lib/python3.12/site-packages/MySQLdb/_mysql.cpython-312-darwin.so lib/python3.12/site-packages/MySQLdb/_mysql.cpython-312-darwin.so: Mach-O 64-bit bundle x86_64 The binary file from python is also arm64 based $ file "$(which python)" /pathToPython/bin/python: Mach-O 64-bit executable arm64 Where should I report this Issue? How should I debug it? I already reinstalled python and mysql, deactivated Rosetta on my terminal. Continue reading...